Type I Tumor Necrosis Factor Receptors

A tumor necrosis factor receptor subtype that has specificity for TUMOR NECROSIS FACTOR ALPHA and LYMPHOTOXIN ALPHA. It is constitutively expressed in most tissues and is a key mediator of tumor necrosis factor signaling in the vast majority of cells. The activated receptor signals via a conserved death domain that associates with specific TNF RECEPTOR-ASSOCIATED FACTORS in the CYTOPLASM.

Also Known As:

Receptors, Tumor Necrosis Factor, Type I; CD 120a Antigen; CD120a Antigen; TNFR p60; TNFR-I; TNFR1; TNFRSF1A (Tumor Necrosis Factor Receptor Superfamily, Member 1A); TNFRSF1A Receptor; Tumor Necrosis Factor Receptor 1A; Tumor Necrosis Factor Receptor Type 1; 120a Antigen, CD; Antigen, CD 120a; Antigen, CD120a; Receptor, TNFRSF1A; Antigens, CD120a; CD120a Antigens; Receptors, Tumor Necrosis Factor, Member 1A; Tumor Necrosis Factor Receptor Superfamily, Member 1A; Tumor Necrosis Factor Receptor Type I

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Membrane Proteins: 10078
    - Cell Surface Receptors: 2125
      - Death Domain Receptors: 2368
        Type I Tumor Necrosis Factor Receptors: 1178
      - Immunologic Receptors: 9
        Cytokine Receptors: 1620
        Tumor Necrosis Factor Receptors: 3685
        Type I Tumor Necrosis Factor Receptors: 1178

J F Mangin Selected Research

J F Mangin Research Topics

Disease

Drug/Important Bio-Agent (IBA)